Monitor Closely (one)mitotane decreases amounts of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Mitotane is a robust inducer of cytochrome P-4503A4; check when coadministered with CYP3A4 substrates for achievable dosage adjustments.Ergotamine: Alpha-adrenergic blocking agent with immediate stimulating effe… Read More